Research on the Mineral Selenium
The following articles are presented as a reflection for
the use of ionic minerals selenium as a dietary supplement and nutritional supplement. You
will find more on selenium here. You can also
purchase this diet supplement below.
Am J Clin Nutr. 1995 Dec. 62(6 Suppl). P 1477S-1482S
The people of Linxian County, China have one of the world's
highest rates of esophageal cancer. Two intervention trials were conducted to determine
whether supplementation with specific vitamins and minerals could lower mortality from or
incidence of cancer in this population and whether supplementation with multiple vitamins
and minerals would reduce esophageal and gastric cardia cancer in persons with esophageal
dysplasia. About 30,000 general population (GP) subjects in the GP trial were randomly
assigned to one of eight intervention groups according to a one-half replicate of a 2(4)
factorial experimental design and were supplemented for 5.25 y with four combinations of
micronutrients at doses from one to two times the US recommended dietary allowance (RDA).
About 3000 subjects in whom dysplasia was diagnosed in the dysplasia trial were randomly
assigned to groups receiving daily supplementation with 14 vitamins and 12 minerals at two
to three times the US RDA or placebo for 6 y. Results of the dysplasia trial indicate that
in individuals with esophageal dysplasia, micronutrient supplementation had little effect
on T lymphocyte responses. In contrast, male participants in the GP trial who were
supplemented with beta-carotene, vitamin E, and selenium
showed significantly (P <0.05) higher mitogenic responsiveness of T lymphocytes in
vitro than those not receiving these micronutrients.
CANCER RES. (USA) , 1994, 54/7 SUPPL. (1957s-1959s)
This presentation focuses on research that could
theoretically be applied to implement the strategy of general population chemoprevention.
The concept is based on the premise of enhancing foods with known anticarcinogens through
either agricultural methods or food-processing technologies. Two areas of our work are
described: (a) garlic cultivated with selenium fertilization
and (b) foods high in conjugated linoleic acid. Both selenium
and conjugated linoleic acid are powerful chemopreventive agents in the animal tumor
model. The rationale of delivering these two specific compounds through the food system
will be developed. Preliminary studies will be su carcinogen-induced mammary cancer in
rats. Finally, the advantages of using foods to provide anticarcinogens to the general
population as part of a chemopreventive strategy will also be discussed.
Carcinogenesis (United Kingdom) , 1996, 17/9 (1979-1982)
Previous work has shown that the efficacy of cancer
prevention by selenium-enriched garlic (Se-garlic) is
primarily dependent on the action of selenium. Additionally,
supplementation of Se-garlic inhibited the post-initiation phase of mammary carcinogenesis
when it was given continuously to the animals. In this report, experiments were carried
out in which treatment with the Se-garlic was started after carcinogen dosing (DMBA or
MNU) but was restricted to either the early or late stage of neoplastic progression. The
results from these two models showed that a short-term exposure to the Se-garlic for 1
month immediately following carcinogen administration was just as effective in cancer
prevention as the continuous exposure regimen (5 months), suggesting that the Se-garlic
may irreversibly alter the process of clonal expansion and/or selection of transformed
cells during their early stage of development. Plasma and mammary tissue selenium levels essentially returned to basal levels at 1 month
after withdrawal of supplementation. These observations imply that the outcome of cancer
protection by short-term Se-garlic intervention was not due to a slow turnover, and
therefore a lingering presence, of selenium in the target
organ or in the circulation. The above finding was in contrast to that of a second study
in which Se-garlic was supplemented starting at 13 weeks after carcinogen treatment. With
this protocol, the number of new tumors and the number of new tumor-bearing rats found
during the intervention period (weeks 13 to 22) were not statistically different between
the control and supplemented groups, suggesting that Se-garlic had a minimal effect on the
later stages of mammary carcinogenesis.
Carcinogenesis (United Kingdom) , 1996, 17/9 (1903-1907)
Previous work has shown that the efficacy of cancer
prevention by selenium-enriched garlic (Se-garlic) is
primarily dependent on the action of selenium. An aqueous
extract containing 43 microg Se/ml was prepared from lyophilized Se-garlic powder by the
Soxhlet method. The activity of this Se-garlic extract was evaluated in a transformed
mammary epithelial cell culture model for its effect on cell morphology, cell growth, cell
cycle progression and the induction of single and double stranded breaks in DNA.
Comparisons were also made with a similarly prepared extract from regular garlic,
Se-methylselenocysteine (a major water-soluble seleno-amino acid identified in Se-garlic)
and selenite (used for fertilizing Se-garlic). In contrast to the regular garlic extract
which produced little or no modulation of the above parameters, treatment with the
Se-garlic extract resulted in growth inhibition, G1 phase cell cycle arrest and apoptotic
DNA double strand breaks in the absence of DNA single strand breaks. This pattern of
cellular responses was duplicated with exposure to Se-methylselenocysteine. Selenite, on
the other hand, induced cell cycle blockage in the S/G2-M phase, and a marked increase in
DNA single strand breaks (a measure of genotoxicity) in addition to growth suppression.
The chemopreventive efficacy of the two garlic extracts was also investigated in the rat
methylnitrosourea mammary tumor model. Both extracts were supplemented in the diet for 1
month immediately following carcinogen administration. Significant cancer protection was
observed with treatment by the Se-garlic extract (at 3 p.p.m. Se in the diet), while
little benefit was noted with treatment by the regular garlic extract. Based on the above
in vitro and in who findings, it is hypothesized that the Se-garlic extract, in part via
the action of Se-methylselenocysteine, is able to inhibit tumorigenesis by suppressing the
proliferation and reducing the survival of the early transformed cells. Furthermore, the
data also support the concept that the moduss of novel forms of selenium
for cancer prevention.
GAZZ.SANIT. (MILANO) (ITALY), 1973, 22/1 (37-39)
The incidence of multiple sclerosis among predisposed
subjects is higher in cold climates, and is compounded where trace metals, such as copper,
selenium and cobalt, are lacking in the diet. The importance
of trace elements in various metabolic processes is discussed, including the etiology of
multiple sclerosis. Screening children, removing those at risk to warmer climates and
further research into trace metal physiology are recommended.
Mail Order Form Click
Here!
View Shopping Cart / Checkout